Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein (BTC) (Active)

Product Description

Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein (BTC) (Active) is available at Gentaur for Next week Delivery.

Gene Name: BTC

Alternative Names : BTC,

Expression Region : 32-111aa

AA Sequence : DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 9.0 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4, with 0.02 % Tween-20

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 0.05 ng/ml, corresponding to a specific activity of ? 2.0 × 107 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. {ECO:0000269|PubMed:8570211}.

Function : Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Involvement in disease :

Subcellular location : Betacellulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Probetacellulin: Cell membrane, Single-pass type I membrane protein

Protein Families :

Tissue Specificity : Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.

Paythway : ErbBsignalingpathway

Uniprot ID : P35070