Recombinant Human Sonic hedgehog protein (SHH) (Active)

Product Description

Recombinant Human Sonic hedgehog protein (SHH) (Active) is available at Gentaur for Next week Delivery.

Gene Name: SHH

Alternative Names : SHH,

Expression Region : 25-197aa

AA Sequence : IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKISRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 19.8 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by inducing alkaline phosphatase production of murine C3H/10T1/2 cells is less than 1 ?g/ml, corresponding to a specific activity of ? 1.0 × 103 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity). {ECO:0000250}.

Function : Sonic hedgehog protein

Involvement in disease : Microphthalmia, isolated, with coloboma, 5 (MCOPCB5); Holoprosencephaly 3 (HPE3); Solitary median maxillary central incisor (SMMCI); Triphalangeal thumb-polysyndactyly syndrome (TPTPS); Preaxial polydactyly 2 (PPD2); Hypoplasia or aplasia of tibia with polydactyly (THYP); Laurin-Sandrow syndrome (LSS)

Subcellular location : Sonic hedgehog protein N-product: Cell membrane, Lipid-anchor

Protein Families : Hedgehog family

Tissue Specificity :

Paythway : Hedgehogsignalingpathway

Uniprot ID : Q15465