Recombinant Human Trimethylguanosine synthase (TGS1), partial

Product Description

Recombinant Human Trimethylguanosine synthase (TGS1), partial is available at Gentaur for Next week Delivery.

Gene Name: TGS1

Alternative Names : CLL-associated antigen KW-2;Cap-specific guanine-N2 methyltransferaseHepatocellular carcinoma-associated antigen 137Nuclear receptor coactivator 6-interacting protein;PRIP-interacting protein with methyltransferase motif;PIMT;PIPMT

Expression Region : 713-853aa

AA Sequence : MRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASFLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPASET

Sequence Info : Partial

Tag Info : N-terminal 6xHis-SUMO-tagged

Theoretical MW : 31.6 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Epigenetics and Nuclear Signaling

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Function : Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Involvement in disease :

Subcellular location : Cytoplasm, Nucleus, Cajal body, Nucleus, nucleolus

Protein Families : Methyltransferase superfamily, Trimethylguanosine synthase family

Tissue Specificity : Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.

Paythway :

Uniprot ID : Q96RS0