Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein (TNFRSF11A) (Active)

Product Description

Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein (TNFRSF11A) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TNFRSF11A,RANK

Alternative Names : Osteoclast differentiation factor receptor, Receptor activator of NF-KB, CD antigen CD265

Expression Region : 29-202aa

AA Sequence : QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KCTTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVCDTGKAL VAVVAGNSTT PRRCACTAGY HWSQDCECCR RNTECAPGLG AQHPLQLNKD TVCKPCLAGY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 19.1 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered 20 mM Tris-HCl, pH 8.0, 150mM NaCl

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of ? 2.0 × 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:9878548}.

Function : Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

Involvement in disease : Familial expansile osteolysis (FEO); Paget disease of bone 2, early-onset (PDB2); Osteopetrosis, autosomal recessive 7 (OPTB7)

Subcellular location : Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform RANK-e5a: Cell membrane, Single-pass type I membrane protein

Protein Families :

Tissue Specificity : Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Paythway : NF-kappaBsignalingpathway

Uniprot ID : Q9Y6Q6