Recombinant Human Tumor necrosis factor receptor superfamily member 12A protein (TNFRSF12A) (Active)

Product Description

Recombinant Human Tumor necrosis factor receptor superfamily member 12A protein (TNFRSF12A) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TNFRSF12A,FN14

Alternative Names : Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, TweakR, CD antigen CD266,

Expression Region : 28-80aa

AA Sequence : EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 5.6 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by inhibiting TWEAK- dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30 ng/ml, corresponding to a specific activity of ? 3.3 × 104 IU/mg, in the presence of 15 ng/ml of rHuTWEAK.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.

Function : Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Involvement in disease :

Subcellular location : Membrane, Single-pass type I membrane protein

Protein Families :

Tissue Specificity : Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Paythway :

Uniprot ID : Q9NP84