Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) (Active)

Product Description

Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) (Active) is available at Gentaur for Next week Delivery.

Gene Name: Ccl5,Scya5

Alternative Names : MuRantes, Small-inducible cytokine A5, T-cell-specific protein RANTES

Expression Region : 24-91aa

AA Sequence : SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 7.9 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The biological activity determined by a chemotaxis bioassay using human T lymphocytes is in a concentration range of 1.0-10 ng/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. {ECO:0000250|UniProtKB:P13501}.

Function : Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.

Involvement in disease :

Subcellular location : Secreted

Protein Families : Intercrine beta (chemokine CC) family

Tissue Specificity : T-cell and macrophage specific.

Paythway :

Uniprot ID : P30882