Recombinant Mouse Ventricular zone-expressed PH domain-containing protein 1 (Veph1), partial

Product Description

Recombinant Mouse Ventricular zone-expressed PH domain-containing protein 1 (Veph1), partial is available at Gentaur for Next week Delivery.

Gene Name: Veph1

Alternative Names : Protein melted homolog (Veph)

Expression Region : 660-833aa

AA Sequence : AMTESTFPQQKDLEQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTHYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDSKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL

Sequence Info : Partial

Tag Info : N-terminal 10xHis-tagged and C-terminal Myc-tagged

Theoretical MW : 27.7 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Others

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.

Function : Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.

Involvement in disease :

Subcellular location : Cell membrane, Peripheral membrane protein, Cytoplasmic side

Protein Families : MELT/VEPH family

Tissue Specificity : Specifically expressed in kidney and eye. In the eye, expressed in retinal pigmented epithelium but not in the neural retina.

Paythway :

Uniprot ID : A1A535