Anti 8-OHdG monoclonal antibody (N45.1)

Product Description

Anti 8-OHdG monoclonal antibody (N45.1) is available at Gentaur for Next Week Delivery.

Description:  Reactive oxygen species (ROS) and oxidative stress may be crucial for development of various diseases such as diabetes, cancer, and may play an important role in the aging process. 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a product of oxidatively damaged DNA formed by hydroxy radical, singlet oxygen and direct photodynamic action. 8-OHdG can be detected in tissue, serum, urine and other biomaterials. Anti 8-OHdG monoclonal antibody (clone N45.1) is highly specific for DNA damage, not cross react with RNA oxidation products such as 8-hydroxy-guanine and 8-hydroxy-guanosine. Suitable for immunohistochemistry and ELISA.

More Information:  Epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment stained with N45.1. (Y.Hattori, et.al.: J Invest Dermatol 107, p733-737, 1996)

Assay principle: 

Specifity:  19 analogues of 8-OHdG {guanosine (G), 7-methyl-G, 6-SH-G, 8-bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine (Gua), O6-methyl-Gua, 8-OHGua, uric acid, Urea, creatine, creatinine} demonstrate no cross-reactivity. Only 8-sulfhydryl-G and 8-OHG demonstrate minimal cross-reactivity (less than 1%).

Measuring range: 

Form: Lyophilized Powder

Antigen: 8-OHdG-conjugated Keyhole Limpet Hemocyanin

Applications:  Immunohistochemistry and ELISA

Storage:  Less than -20°C for 5 years When transport, stable at least 7 days at room temperature.

Expiry: 

Required but not provided: 

Remarq:  Low cross reactivity to 8-OHGua/8-OHG.