Beta Synuclein Protein is available at Gentaur for Next week delivery.
Description: Active Human Recombinant Beta Synuclein Protein Preformed Fibrils (Type 1)
Alternative Name(s): 14 kDa brain-specific protein aggregates, Beta-synuclein Protein Aggregates, Phosphoneuroprotein 14 Protein Aggregates, PNP14 Protein Aggregates, Sncb Protein Aggregates, Synuclein beta Protein Aggregates, SYUB_HUMAN Protein Aggregates
Research Area(s): Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Accession Number: NP_001001502.1
Gene ID: 6620
Applications Species: WB | SDS-PAGE | In vivo assay | In vitro assay
Expression System: E. coli
Protein Length: Full length
Amino Acid Sequence:
Purification: Ion-exchange Purified
Storage Buffer: PBS pH 7.4
Concentration: Lot/batch specific. See included datasheet.
Shipping Temperature: Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Other relevant information: For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or on the product datasheet for further information..
Certificate of Analysis: Certified >95% pure using SDS-PAGE analysis.
Cellular Localization: Cytoplasm
Scientific Background: Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Beta synuclein is abundant in neurofibrillary lesions of patients with Alzheimer's Disease. Beta synuclein is suggested to be an inhibitor of alpha synuclein aggregation- protecting the central nervous system from the neurotoxin effects of alpha synuclein (3).
References: 1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907). 3. Taschenberger G., et al. (2013) Ann Neurol. 74(1): 109-118.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Published Species Reactivity:"